Effects of Dorzolamide on Choroidal Blood Flow, Ciliary Blood Flow, and Aqueous Production in Rabbits
نویسندگان
چکیده
منابع مشابه
Effects of dorzolamide on choroidal blood flow, ciliary blood flow, and aqueous production in rabbits.
PURPOSE To determine the effects of topical dorzolamide (a carbonic anhydrase inhibitor) on choroidal and ciliary blood flow and the relationship between ciliary blood flow and aqueous flow. METHODS The experiments were performed in four groups of pentobarbital-anesthetized rabbits treated with topical dorzolamide (2%, 50 microL). In all groups, intraocular pressure (IOP) and mean arterial pr...
متن کاملRelationship between ciliary blood flow and aqueous production in rabbits.
PURPOSE To determine the relationship between ciliary blood flow and aqueous flow by changing the mean arterial pressure (MAP) mechanically under controlled conditions in an animal model. METHODS In anesthetized rabbits, MAP and intraocular pressure (IOP) were measured by direct cannulation. MAP was controlled with occluders placed on the aorta and vena cava. In group 1 (n = 22), aqueous flow...
متن کاملEffects of dopamine on ciliary blood flow, aqueous production, and intraocular pressure in rabbits.
PURPOSE Dopamine is a known modulator of cardiovascular function and intraocular pressure (IOP). In this study, the authors investigate the dose-dependent effects of dopamine on IOP, ciliary hemodynamics, and aqueous production in anesthetized rabbits to test the hypothesis that aqueous production becomes blood-flow-dependent if ciliary perfusion declines below some unknown critical level. ME...
متن کاملEffects of acetazolamide on choroidal blood flow.
BACKGROUND AND PURPOSE The acetazolamide provocation test is commonly used to study cerebrovascular vasomotor reactivity. On the basis of the effect of a carbonic anhydrase inhibitor in the central nervous system, we hypothesized that acetazolamide may also increase blood flow in the human choroid. METHODS In a placebo-controlled, randomized, double-blind, three-way crossover design, acetazol...
متن کاملDorzolamide effect on ocular blood flow.
PURPOSE To evaluate the effect of dorzolamide on ocular blood flow in normal and glaucomatous eyes. METHODS Twenty-six eyes with documented open-angle glaucoma of 26 patients and 13 normal control eyes of 8 age-matched subjects were included in this study. All eyes underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, and resistance index in the ophthal...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2009
ISSN: 1552-5783
DOI: 10.1167/iovs.08-2468